Nature Communications (Dec 2019)
A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
- Peter G. Boone,
- Lauren K. Rochelle,
- Joshua D. Ginzel,
- Veronica Lubkov,
- Wendy L. Roberts,
- P. J. Nicholls,
- Cheryl Bock,
- Mei Lang Flowers,
- Richard J. von Furstenberg,
- Barry R. Stripp,
- Pankaj Agarwal,
- Alexander D. Borowsky,
- Robert D. Cardiff,
- Larry S. Barak,
- Marc G. Caron,
- H. Kim Lyerly,
- Joshua C. Snyder
Affiliations
- Peter G. Boone
- Division of Surgical Sciences, Department of Surgery, Duke University School of Medicine
- Lauren K. Rochelle
- Division of Surgical Sciences, Department of Surgery, Duke University School of Medicine
- Joshua D. Ginzel
- Department of Cell Biology, Duke University School of Medicine
- Veronica Lubkov
- Division of Surgical Sciences, Department of Surgery, Duke University School of Medicine
- Wendy L. Roberts
- Department of Cell Biology, Duke University School of Medicine
- P. J. Nicholls
- Department of Cell Biology, Duke University School of Medicine
- Cheryl Bock
- Transgenic Mouse Facility, Duke Cancer Institute
- Mei Lang Flowers
- Transgenic Mouse Facility, Duke Cancer Institute
- Richard J. von Furstenberg
- Division of Gastroenterology, Department of Medicine, Duke University School of Medicine
- Barry R. Stripp
- Department of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center
- Pankaj Agarwal
- Division of Surgical Sciences, Department of Surgery, Duke University School of Medicine
- Alexander D. Borowsky
- Department of Pathology and Laboratory Medicine and The Center for Comparative Medicine, University of California-Davis
- Robert D. Cardiff
- Department of Pathology and Laboratory Medicine and The Center for Comparative Medicine, University of California-Davis
- Larry S. Barak
- Department of Cell Biology, Duke University School of Medicine
- Marc G. Caron
- Department of Cell Biology, Duke University School of Medicine
- H. Kim Lyerly
- Division of Surgical Sciences, Department of Surgery, Duke University School of Medicine
- Joshua C. Snyder
- Division of Surgical Sciences, Department of Surgery, Duke University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-13330-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Pre-malignant cells harbouring oncogenic mutations can populate and spread throughout a tissue. Here, using a rainbow mouse system, the authors explore how clonal expansion in the mouse intestine might explain high levels of intra-tumoural heterogeneity observed in the disease.
