Multi-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats

Robin Mesnage; Maxime Teixeira; Daniele Mandrioli; Laura Falcioni; Mariam Ibragim; Quinten Raymond Ducarmon; Romy Daniëlle Zwittink; Caroline Amiel; Jean-Michel Panoff; Emma Bourne; Emanuel Savage; Charles A. Mein; Fiorella Belpoggi; Michael N. Antoniou

doi:10.1038/s42003-021-01990-w

Communications Biology (Apr 2021)

Multi-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats

Robin Mesnage,
Maxime Teixeira,
Daniele Mandrioli,
Laura Falcioni,
Mariam Ibragim,
Quinten Raymond Ducarmon,
Romy Daniëlle Zwittink,
Caroline Amiel,
Jean-Michel Panoff,
Emma Bourne,
Emanuel Savage,
Charles A. Mein,
Fiorella Belpoggi,
Michael N. Antoniou

Affiliations

Robin Mesnage: Gene Expression and Therapy Group, King’s College London, Faculty of Life Sciences & Medicine, Department of Medical and Molecular Genetics, Guy’s Hospital
Maxime Teixeira: UR Aliments Bioprocédés Toxicologie Environnements, EA 4651, University of Caen Normandy (UCN)
Daniele Mandrioli: Ramazzini Institute (RI)
Laura Falcioni: Ramazzini Institute (RI)
Mariam Ibragim: Gene Expression and Therapy Group, King’s College London, Faculty of Life Sciences & Medicine, Department of Medical and Molecular Genetics, Guy’s Hospital
Quinten Raymond Ducarmon: Center for Microbiome Analyses and Therapeutics, Leiden University Medical Center
Romy Daniëlle Zwittink: Center for Microbiome Analyses and Therapeutics, Leiden University Medical Center
Caroline Amiel: UR Aliments Bioprocédés Toxicologie Environnements, EA 4651, University of Caen Normandy (UCN)
Jean-Michel Panoff: UR Aliments Bioprocédés Toxicologie Environnements, EA 4651, University of Caen Normandy (UCN)
Emma Bourne: Genome Centre, Barts and the London School of Medicine and Dentistry, Blizard Institute
Emanuel Savage: Genome Centre, Barts and the London School of Medicine and Dentistry, Blizard Institute
Charles A. Mein: Genome Centre, Barts and the London School of Medicine and Dentistry, Blizard Institute
Fiorella Belpoggi: Ramazzini Institute (RI)
Michael N. Antoniou: Gene Expression and Therapy Group, King’s College London, Faculty of Life Sciences & Medicine, Department of Medical and Molecular Genetics, Guy’s Hospital

DOI: https://doi.org/10.1038/s42003-021-01990-w
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

Read online

Using a multi-omics platform, Mesnage et al present an extensive dataset that reports the effects of low-dose pesticides frequently detected in food on Sprague-Dawley rats. This study suggests potential metabolic biomarkers that may predict health risks from exposure to chemical pollutants.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal