Haematologica (May 2008)

Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma

  • Judith Dierlamm,
  • Eva M. Murga Penas,
  • Stefan Bentink,
  • Swen Wessendorf,
  • Hilmar Berger,
  • Michael Hummel,
  • Wolfram Klapper,
  • Dido Lenze,
  • Andreas Rosenwald,
  • Eugenia Haralambieva,
  • German Ott,
  • Sergio B. Cogliatti,
  • Peter Möller,
  • Carsten Schwaenen,
  • Harald Stein,
  • Markus Löffler,
  • Rainer Spang,
  • Lorenz Trümper,
  • Reiner Siebert,
  • for the Deutsche Krebshilfe Network Project “Molecular Mechanisms in Malignant Lymphomas”

DOI
https://doi.org/10.3324/haematol.12057
Journal volume & issue
Vol. 93, no. 5

Abstract

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Background The aim of this study was to determine the impact of a gain of the MALT1 gene on gene expression and clinical parameters in diffuse large B-cell lymphoma.Design and Methods We analyzed 116 cases of diffuse large B-cell lymphoma by fluorescence in situ hybridization, array-based comparative genomic hybridization, and transcriptional profiling.Results A gain of 18q21 including MALT1 was detected in 44 cases (38%) and was accompanied by a gain of BCL2 in 43 cases. All cases with a 18q21/MALT1 gain showed BCL2 protein whereas 79% in the group without a 18q21/MALT1 gain did so (p