Evaluation of oxidative stress factors in patients with osteoporosis

Abstract

Osteoporosis is an important disease with an increasing incidence that leads to serious losses in physical function and adversely affecting the life quality of women especially in postmenopausal period. Age, genetic structure, vitamin D and K abnormalities, estrogen deficiency, chronic inflammation and oxidative stress are considered among the most important risk factors for osteoporosis. Therefore, we aimed to investigate the plasma paraoxonase (PON1) activity, high-density lipoprotein (HDL), total sialic acid (TSA) and total oxidant/antioxidant status (TOS/TAS) of patients with osteoporosis in this study. Comparisons of 25 female patients diagnosed with osteoporosis aged between 51-67 and 10 healthy women between the ages ranged 50-68 were made in this study. PON1 activity, HDL, TSA, TOS and TAS levels were measured by spectrophotometrical method in plasma samples that obtained from blood samples of patients and healthy individuals. Results were expressed as mean ± standard deviation. Plasma PON1 activity, TAS and HDL levels were significantly lower in patiens with osteoporosis than the healty group (p [Med-Science 2017; 6(3.000): 479-82]

Keywords

• Osteoporosis
• paraoxonase activity
• total sialic acid
• total oxidant status
• total antioxidant status