Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions

Parker J. Nichols; Shaun Bevers; Morkos Henen; Jeffrey S. Kieft; Quentin Vicens; Beat Vögeli

doi:10.1038/s41467-021-21039-0

Nature Communications (Feb 2021)

Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions

Parker J. Nichols,
Shaun Bevers,
Morkos Henen,
Jeffrey S. Kieft,
Quentin Vicens,
Beat Vögeli

Affiliations

Parker J. Nichols: Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine
Shaun Bevers: Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine
Morkos Henen: Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine
Jeffrey S. Kieft: Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine
Quentin Vicens: Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine
Beat Vögeli: Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine

DOI: https://doi.org/10.1038/s41467-021-21039-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

Read online

ADAR1 is an interferon-induced enzyme that catalyzes editing of adenine to inosine across the transcriptome as part of the immune response. Here the authors establish how ADAR1 recognizes non-CpG RNA sequences to facilitate the formation of A-Z junctions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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