PLoS ONE (Jan 2016)

Association of Right Ventricular Pressure and Volume Overload with Non-Ischemic Septal Fibrosis on Cardiac Magnetic Resonance.

  • Jiwon Kim,
  • Chaitanya B Medicherla,
  • Claudia L Ma,
  • Attila Feher,
  • Nina Kukar,
  • Alexi Geevarghese,
  • Parag Goyal,
  • Evelyn Horn,
  • Richard B Devereux,
  • Jonathan W Weinsaft

DOI
https://doi.org/10.1371/journal.pone.0147349
Journal volume & issue
Vol. 11, no. 1
p. e0147349

Abstract

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Non-ischemic fibrosis (NIF) on cardiac magnetic resonance (CMR) has been linked to poor prognosis, but its association with adverse right ventricular (RV) remodeling is unknown. This study examined a broad cohort of patients with RV dysfunction, so as to identify relationships between NIF and RV remodeling indices, including RV pressure load, volume and wall stress.The population comprised patients with RV dysfunction (EF 6-fold more common in the highest, vs. the lowest, common tertile of PASP and RV size (p<0.001).Among wall stress components, NIF was independently associated with RV chamber dilation and afterload, supporting the concept that NIF is linked to adverse RV chamber remodeling.