(22E,24S)-24-Propylcholest-5en-3α-acetate: A New Steroid from the Stembark Aglaia angustifolia (Miq.) (Meliaceae)

Ricson P. Hutagaol; Desi Harneti; Ace T. Hidayat; Nurlelasari; Rani Maharani; Dewa Gede Katja; Unang Supratman; Khalijah Awang; Yoshihito Shiono

doi:10.3390/M1112

Molbank (Jan 2020)

(22E,24S)-24-Propylcholest-5en-3α-acetate: A New Steroid from the Stembark Aglaia angustifolia (Miq.) (Meliaceae)

Ricson P. Hutagaol,
Desi Harneti,
Ace T. Hidayat,
Nurlelasari,
Rani Maharani,
Dewa Gede Katja,
Unang Supratman,
Khalijah Awang,
Yoshihito Shiono

Affiliations

Ricson P. Hutagaol: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Nusa Bangsa University, Bogor 16166, West Java, Indonesia
Desi Harneti: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, West Java, Indonesia
Ace T. Hidayat: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, West Java, Indonesia
Nurlelasari: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, West Java, Indonesia
Rani Maharani: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, West Java, Indonesia
Dewa Gede Katja: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sam Ratulangi, Kampus Bahu, Manado 95115, North Sulawesi, Indonesia
Unang Supratman: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, West Java, Indonesia
Khalijah Awang: Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 59100, Malaysia
Yoshihito Shiono: Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan

DOI: https://doi.org/10.3390/M1112
Journal volume & issue: Vol. 2020, no. 1
p. M1112

Abstract

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A new propylcholesterol-type steroid, namely (22E,24S)-24-propylcholest-5en-3α-acetate (1), has been isolated from the stembark of Aglaia angustifolia (Miq.). The structure of 1 was determined on the basis of spectroscopic data including 1D- and 2D-NMR as well as high resolution mass spectroscopy analysis. Compound 1 showed weak activity against the MCF-7 breast cancer cell line.

Published in Molbank

ISSN: 1422-8599 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Inorganic chemistry
Website: https://www.mdpi.com/journal/molbank

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