eJHaem (Dec 2024)

Extramedullary disease in Waldenström macroglobulinemia: A population‐based observational study

  • Simon Østergaard,
  • Lars Munksgaard,
  • Torsten Holm Nielsen,
  • Troels Hammer,
  • Lars Møller Pedersen,
  • Mette Ølgod Pedersen,
  • Lise Mette Rahbek Gjerdrum

DOI
https://doi.org/10.1002/jha2.1037
Journal volume & issue
Vol. 5, no. 6
pp. 1269 – 1273

Abstract

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Abstract Introduction: Extramedullary disease (EMD) is a rare manifestation of Waldenström macroglobulinemia (WM), and its clinical and prognostic implications are poorly understood. Methods: In this single‐center study, we investigated the clinical significance of EMD in a cohort of 469 WM patients. Results: EMD was identified in 30 (6.4%) patients, with the central nervous system, kidneys, and lungs being the most frequently affected sites. The cumulative incidence of EMD was 12.6% at 15 years. Median overall survival rates at 5 and 10 years for patients with EMD were 63% and 37%, respectively. Conclusion: Our findings indicate a persistent risk of EMD throughout the disease course, with no significant impact on long‐term survival.

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