Frontiers in Oncology (Jan 2023)

High-dose cytarabine monotherapy is superior to standard-dose cytarabine- based multiagent sequential treatment cycle for consolidation treatment in adult (14-59 years) AML patients according to European Leukemia Net 2022 risk stratification

  • Xiaoyu Wang,
  • Dan Liu,
  • Erling Chen,
  • Li Wang,
  • Na Zhao,
  • Li Zhou,
  • Juan Tong,
  • Lei Xue,
  • Lei Zhang,
  • Liangquan Geng,
  • Baolin Tang,
  • Huilan Liu,
  • Xin Liu,
  • Changcheng Zheng,
  • Changcheng Zheng

DOI
https://doi.org/10.3389/fonc.2022.1070588
Journal volume & issue
Vol. 12

Abstract

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IntroductionWe firstly investigate based on 2022 European Leukemia Net (ELN) risk stratification, whether standard-dose cytarabine based multiagent sequential chemotherapy (SDMSC) is more beneficial than high-dose cytarabine (HDAC) monotherapy in consolidation for the survival of adult acute myeloid leukemia (AML) patients.MethodsOne hundred and eighty-three AML patients with complete remission (CR) were evaluated.Results and discussionThe 3-year relapse rate was 33.4% in the HDAC group and 50.5% in the SDMSC group (p=0.066). The 3-year overall survival (OS) and event-free survival (EFS) rates in the HDAC group (69.2%, 60.7%) were significantly higher than that in the SDMSC group (50.8%, 42.1%) (p=0.025, 0.019). For patients in the intermediate risk group, the 3-year OS and EFS rates in the HDAC group (72.5%, 56.7%) were higher than that in the SDMSC group (49.1%, 38.0%) (p=0.028, 0.093). This study indicates that for young adult AML patients, HDAC consolidation achieves a higher long-term survival than SDMSC, especially for patients in the intermediate-risk group according to the 2022 ELN risk stratification.

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