EFFECT OF CHEMOTHERAPY WITH DOCETAXEL / CISPLATIN ON GRANULOCYTIC HEMOPOIESIS IN PATIENTS WITH NON-SMALL CELL LUNG CARCINOMA

Abstract

Toxic effects of combined cisplatin and docetaxel treatment on the granulocytic hemopoiesis were studied in 45 patients with stage II–IV non-small cell lung carcinoma. The patients received intravenous injections of docetaxel at a dose of 75 mg/m2 followed by cisplatin 75 mg/m2. Blood parameters were assessed during 3 courses of chemotherapy. To estimate the state of granulocytic hemopoiesis, the hematological, cultural and functional methods were used. The study showed that the reactivity of granulocytopoiesis was maintained at a high level, namely, there was a significant activation of the central signals of granulocytic hematopoiesis, resulting in the accumulation of immature and mature myelokaryocytes in the bone marrow and increase in the bone marrow pool of mature neutrophils, as well as in increase in the number of bone marrow progenitor cells granulocytopoiesis in terms of acceleration of their maturing.

Keywords

• lung cancer
• chemotherapy
• granulocytopoiesis
• docetaxel
• cisplatin