Nature Communications (Sep 2018)

Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target

  • Emilio Yángüez,
  • Annika Hunziker,
  • Maria Pamela Dobay,
  • Soner Yildiz,
  • Simon Schading,
  • Elizaveta Elshina,
  • Umut Karakus,
  • Peter Gehrig,
  • Jonas Grossmann,
  • Ronald Dijkman,
  • Mirco Schmolke,
  • Silke Stertz

DOI
https://doi.org/10.1038/s41467-018-06119-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Influenza A virus (IAV) causes annual epidemics and development of antivirals is needed. Here, the authors perform phosphoproteomics during IAV entry and identify GRK2 as drug target, inhibition of which decreases replication of seasonal and pandemic IAV in primary human cells and animal models.