Monoclonal Antibodies and Recombinant Proteins for Immune-Diagnostics of Ebola Virus Disease

Abstract

The review summarizes the literature data on the studies of viral antigens and antibodies, specific to Ebola virus, suitable for the development of a test-system for immune-diagnostics of the disease caused by them. Represented are the results of investigations on the obtainment of hybridoma monoclonal antibodies (MCA), specific to structural viral proteins NP, VP40, and VP35; recombinant proteins NP, VP40, and VP35 in prokaryotic system of E. coli; as well as the possibility to utilize MCA panels for EV viral and recombinant proteins’ detection in ELISA.

Keywords

• вирус эбола
• рекомбинантные белки
• моноклональные антитела
• иммунодиагностика
• ebola virus
• recombinant proteins
• monoclonal antibodies
• immune-diagnostics