The synthesis of functionalized bridged polycycles via C–H bond insertion

Abstract

This review presents examples from the chemical literature of syntheses of bridged-polycyclic products via C–H bond insertion by carbenes and nitrenes. Applications to natural product synthesis, a description of the essential elements in substrate-controlled reactions, and mechanistic details of transformations are presented. Overall, these transformations allow the construction of important ring systems rapidly and efficiently, though additional catalyst development is needed.

Keywords

• bridged rings
• carbene
• cascade reaction
• C–H bond insertion
• nitrene