Nature Communications (Mar 2020)
CDK1 dependent phosphorylation of hTERT contributes to cancer progression
- Mami Yasukawa,
- Yoshinari Ando,
- Taro Yamashita,
- Yoko Matsuda,
- Shisako Shoji,
- Masaki Suimye Morioka,
- Hideya Kawaji,
- Kumiko Shiozawa,
- Mitsuhiro Machitani,
- Takaya Abe,
- Shinji Yamada,
- Mika K. Kaneko,
- Yukinari Kato,
- Yasuhide Furuta,
- Tadashi Kondo,
- Mikako Shirouzu,
- Yoshihide Hayashizaki,
- Shuichi Kaneko,
- Kenkichi Masutomi
Affiliations
- Mami Yasukawa
- Division of Cancer Stem Cell, National Cancer Center Research Institute
- Yoshinari Ando
- Division of Cancer Stem Cell, National Cancer Center Research Institute
- Taro Yamashita
- Department of Gastroenterology, Kanazawa University Graduate School of Medical Science
- Yoko Matsuda
- Department of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
- Shisako Shoji
- Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research
- Masaki Suimye Morioka
- Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences
- Hideya Kawaji
- Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences
- Kumiko Shiozawa
- Division of Rare Cancer Research, National Cancer Center Research Institute
- Mitsuhiro Machitani
- Division of Cancer Stem Cell, National Cancer Center Research Institute
- Takaya Abe
- Animal Resource Development Unit, RIKEN Center for Life Science Technologies
- Shinji Yamada
- Department of Antibody Drug Development, Tohoku University Graduate School of Medicine
- Mika K. Kaneko
- Department of Antibody Drug Development, Tohoku University Graduate School of Medicine
- Yukinari Kato
- Department of Antibody Drug Development, Tohoku University Graduate School of Medicine
- Yasuhide Furuta
- Animal Resource Development Unit, RIKEN Center for Life Science Technologies
- Tadashi Kondo
- Division of Rare Cancer Research, National Cancer Center Research Institute
- Mikako Shirouzu
- Laboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research
- Yoshihide Hayashizaki
- RIKEN Preventive Medicine and Diagnosis Innovation Program
- Shuichi Kaneko
- Department of Gastroenterology, Kanazawa University Graduate School of Medical Science
- Kenkichi Masutomi
- Division of Cancer Stem Cell, National Cancer Center Research Institute
- DOI
- https://doi.org/10.1038/s41467-020-15289-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Regulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for reverse transcriptase and terminal transferase activities.
