MicroRNA-125b-5p mimic inhibits acute liver failure

Dakai Yang; Qinggong Yuan; Asha Balakrishnan; Heike Bantel; Jan-Henning Klusmann; Michael P. Manns; Michael Ott; Tobias Cantz; Amar Deep Sharma

doi:10.1038/ncomms11916

Nature Communications (Jun 2016)

MicroRNA-125b-5p mimic inhibits acute liver failure

Dakai Yang,
Qinggong Yuan,
Asha Balakrishnan,
Heike Bantel,
Jan-Henning Klusmann,
Michael P. Manns,
Michael Ott,
Tobias Cantz,
Amar Deep Sharma

Affiliations

Dakai Yang: Research Group MicroRNA in Liver Regeneration, Cluster of Excellence REBIRTH, Hannover Medical School
Qinggong Yuan: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School
Asha Balakrishnan: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School
Heike Bantel: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School
Jan-Henning Klusmann: Pediatric Hematology and Oncology, Hannover Medical School
Michael P. Manns: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School
Michael Ott: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School
Tobias Cantz: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School
Amar Deep Sharma: Research Group MicroRNA in Liver Regeneration, Cluster of Excellence REBIRTH, Hannover Medical School

DOI: https://doi.org/10.1038/ncomms11916
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

Read online

miR125b-5p has been associated with acute liver failure. Here the authors show that this miRNA targets Keap1 and activates Nrf2 to inhibit liver cell death after APAP or FAS toxicity, plus they show that a miR125b-5p mimic can inhibit ALF in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal