Dose dependence of the intensity of free radical processes in the peripheral blood of conditionally healthy donors

Abstract

The nature of the dependence of the intensity of free radical processes in the peripheral blood of donors on the dose of radiation in vitro (0.5 - 3.0 Gy) related to the parameters of the prooxidant-antioxidant ratio (PAR) and the content of malonic dialdehyde (MDA) was investigated. The experimentally obtained “dose - effect” dependencies are integrated indicators of processes occurring after irradiation in the blood, they are approximated by the model of linear regression and are characterized by interindividual variability. An increase in the level of MDA up to 172 % in donors' blood plasma with an increase in radiation dose up to 3.0 Gy was found. Using the PAR parameters and the nature of the course of curves "dose - effect", conditionally healthy donors can be divided into two groups, characterized by the growth or decrease in the intensity of free radical processes with the dose.

Keywords

• test irradiation
• peripheral blood
• free radical processes
• “dose - effect” curve.