BMC Gastroenterology (Apr 2024)

Evaluation of the “Burgenland PREvention trial of colorectal cancer Disease with ImmunologiCal Testing” (B-PREDICT)—a population-based colorectal cancer screening program

  • Stefanie BREZINA,
  • Gernot LEEB,
  • Andreas BAIERL,
  • Evelyn GRÄF,
  • Monika HACKL,
  • Philipp HOFER,
  • Harald LANG,
  • Michaela KLEIN,
  • Karl MACH,
  • Remy SCHWARZER,
  • Wilhelm WLASSITS,
  • Andreas PÜSPÖK,
  • Andrea GSUR

DOI
https://doi.org/10.1186/s12876-024-03242-7
Journal volume & issue
Vol. 24, no. 1
pp. 1 – 9

Abstract

Read online

Abstract Background The colorectal cancer (CRC) screening program B-PREDICT is a population based invited two stage screening project using a faecal immunochemical test (FIT) for initial screening followed by a colonoscopy for those with a positive FIT. B-PREDICT was compared with the opportunistic screening colonoscopy (OPP-COL), performed in course of the nationwide screening program. Methods Within B-PREDICT all residents of the Austrian federal state Burgenland, aged between 40 and 80 are annually invited to FIT testing. All individuals who underwent initial colonoscopy in Burgenland between 01/2003 and 12/2014, were included in this study. Individuals from the FIT-triggered invited screening program B-PREDICT were compared with those from the non-FIT triggered OPP-COL. Results 15 133 individuals from B-PREDICT were compared to 10 045 individuals with OPP-COL. CRC detection rates were 1.34% (CI-95%, [1.15; 1.52]) in B-PREDICT compared to 0.54% in OPP-COL (95%-CI, [0.39; 0.68] p < 0.001). The decrease in the age standardized incidence rates of CRC was more pronounced in the population screened with FIT than in the general population screened with colonoscopy. Changes in incidence rates per year were -4.4% (95%-CI, [-5.1; -3.7]) vs. -1.8% (95%-CI, [-1.9; -1.6] p < 0.001). Conclusions B-PREDICT shows a two-fold higher detection rate of CRC as well as HRA compared to OPP-COL.

Keywords