Известия высших учебных заведений. Поволжский регион: Медицинские науки (Dec 2022)

Organometric parameters of the lower jaw of adult rats after implantation of biogenic hydroxyapatite saturated with iron in various concentrations into the tibia

  • O.K. Zenin,
  • V.N. Morozov,
  • E.N. Morozova

DOI
https://doi.org/10.21685/2072-3032-2022-4-5
Journal volume & issue
no. 4

Abstract

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Background. The study was aimed at testing of growth changes in the mandible in rats after implantation of biogenic hydroxyapaite (HA) enhanced with iron in various concentrations (0.05%, 0.15%, and 0.5%) into opening in the tibia. Materials and methods. Adult male rats (n = 126, mean body weight – 140 grams) were distributed into six groups. The 1st group comprised intact animals, the 2nd group consisted of the animals with 2.2 mm round opening in the proximal part of the shaft of both tibiae made for the purpose of fracture modeling. In 3rd group animals the openings in the tibiae were filled with pure HA material OK-015 and in 4th – 6th HA implants were enhanced with iron (iron concentrations were 0.05%, 0.15% and 0.50%). Organometric parameters were performed by means of calipers with 0.05 mm accuracy. Results. Injury to the tibia leads to a decrease in the longitudinal and transverse growth rate of the mandible as compared to intact animals in all observation terms. Manifestations peak was observed on the 30th day of observation. Dimensions of the incisor base exhibit similar tendency only on the 30th and the 90th days of observation. Implantation of HA material into the openings inhibits longitudinal and appositional growth on the 7th and on the 30th day; these values are similar to those of the controls. An increase in the longitudinal dimensions of the mandible resulted from increase of iron concentration up to 0.15%; alongside with this decrease of mandible width was observed. Similar changes in incisor dimensions were observed in comparison with the animals with pure HA implants. Conclusions. Injury of the tibia leads to the decrease in the longitudinal and appositional growth rate of the mandible in all observation terms. It was found that the presence of iron ions in the composition of the implant can normalize the linear dimensions of the organ which were changed under the conditions of a simulated traumatic injury. It has been established that the most appropriate concentration of this microelement in OK- 015 is 0,15%.

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