Romanian Journal of Laboratory Medicine (Apr 2019)
Is there any association between Serum anti-HSP27 antibody level and the presence of metabolic syndrome; population based case-control study
- Sadabadi Fatemeh,
- Heidari-Bakavoli Alireza,
- Esmaily Habibollah,
- Darroudi Susan,
- Tayefi Maryam,
- Asadi Zahra,
- Parizadeh Seyed Mohammad Reza,
- Tavalaie Shima,
- malekzadeh Najmeh,
- Moghaddam Kiana Hosseinpour,
- Moghadam Azam Rastgar,
- Sahebkar Amir Hosein,
- Fereydouni Narges,
- Barati Elham,
- Azarpazhooh Mahmoudreza,
- Hosseini Seyyed Javad,
- Tayyebi Mohammad,
- Ebrahimi Mahmoud,
- Ferns Gordon A.,
- Ghayour-Mobarhan Majid,
- Mouhebati Mohsen
Affiliations
- Sadabadi Fatemeh
- “Department of modern sciences and technologies, Faculty of medicine, Mashhad university of medical sciences, Mashhad, Iran
- Heidari-Bakavoli Alireza
- Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- Esmaily Habibollah
- Department of Biostatistics & Epidemiology, Faculty of Health, Management & Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
- Darroudi Susan
- “Department of modern sciences and technologies, Faculty of medicine, Mashhad university of medical sciences, Mashhad, Iran
- Tayefi Maryam
- Clinical Research unit, Mashhad University of Medical Sciences, Mashhad, Iran
- Asadi Zahra
- Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- Parizadeh Seyed Mohammad Reza
- Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- Tavalaie Shima
- Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- malekzadeh Najmeh
- “Department of modern sciences and technologies, Faculty of medicine, Mashhad university of medical sciences, Mashhad, Iran
- Moghaddam Kiana Hosseinpour
- Department of biology, Faculty of sciences, Ferdowsi University of Mashhad, Mashhad, Iran
- Moghadam Azam Rastgar
- “Department of modern sciences and technologies, Faculty of medicine, Mashhad university of medical sciences, Mashhad, Iran
- Sahebkar Amir Hosein
- Department of Medical Biotechnology, Faculty of medicine, Mashhad University of medical sciences, Mashhad, Iran
- Fereydouni Narges
- “Department of modern sciences and technologies, Faculty of medicine, Mashhad university of medical sciences, Mashhad, Iran
- Barati Elham
- “Department of modern sciences and technologies, Faculty of medicine, Mashhad university of medical sciences, Mashhad, Iran
- Azarpazhooh Mahmoudreza
- Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- Hosseini Seyyed Javad
- Department of Medical Biotechnology, Faculty of medicine, Mashhad University of medical sciences, Mashhad, Iran
- Tayyebi Mohammad
- Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- Ebrahimi Mahmoud
- Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- Ferns Gordon A.
- Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, UK
- Ghayour-Mobarhan Majid
- Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- Mouhebati Mohsen
- Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- DOI
- https://doi.org/10.2478/rrlm-2019-0016
- Journal volume & issue
-
Vol. 27,
no. 2
pp. 179 – 187
Abstract
Background: Heat shock protein 27 (HSP27) is an intracellular chaperone constitutively expressed in many cell types including cardio myocytes and endothelial cells. Circulating levels of HSP27 and anti-HSP27 antibody are higher in patients with CVD. Anti-HSP27 antibody concentrations were also reported to be increased in atherogenesis. We aimed to evaluate serum anti-HSP27 antibody titers in individuals with, or without, MetS in the MASHAD study cohort with large sample size in 6,568 subjects.
Keywords
