The clinical significance of proadrenomedulin level in blood in sepsis patients

Abstract

The objective: to evaluate the current diagnostic and prognostic significance of proadrenomedullin, as well as determine feasibility to expand its use in routine clinical practice.Subjects and methods. The main publications on proadrenomedullin published in the period from 1993 to 2019 were analyzed.Results. Determining the severity of systemic disorders, the possibility of reversing the pathologies and global prognosis are essential aspects in the management of patients, especially those critically ill. Proadrenomedullin stands in good stead in sepsis. Caution in the interpretation should be exercised when patients with sepsis have concomitant acute or chronic cardiovascular diseases and diabetes mellitus. There are certain grounds to suppose that proadrenomedullin possesses some other capabilities. It is necessary to investigate further its prognostic value in combination with other biomarkers, scales and critical non-infectious conditions accompanied by shock.

Keywords

• proadrenomedullin
• sepsis
• biomarkers