Nature Communications (Mar 2021)
Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era
- Anna K. Pöntinen,
- Janetta Top,
- Sergio Arredondo-Alonso,
- Gerry Tonkin-Hill,
- Ana R. Freitas,
- Carla Novais,
- Rebecca A. Gladstone,
- Maiju Pesonen,
- Rodrigo Meneses,
- Henri Pesonen,
- John A. Lees,
- Dorota Jamrozy,
- Stephen D. Bentley,
- Val F. Lanza,
- Carmen Torres,
- Luisa Peixe,
- Teresa M. Coque,
- Julian Parkhill,
- Anita C. Schürch,
- Rob J. L. Willems,
- Jukka Corander
Affiliations
- Anna K. Pöntinen
- Department of Biostatistics, Faculty of Medicine, University of Oslo
- Janetta Top
- Department of Medical Microbiology, University Medical Center Utrecht
- Sergio Arredondo-Alonso
- Department of Biostatistics, Faculty of Medicine, University of Oslo
- Gerry Tonkin-Hill
- Parasites and Microbes, Wellcome Sanger Institute
- Ana R. Freitas
- UCIBIO/REQUIMTE, Laboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy, University of Porto
- Carla Novais
- UCIBIO/REQUIMTE, Laboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy, University of Porto
- Rebecca A. Gladstone
- Department of Biostatistics, Faculty of Medicine, University of Oslo
- Maiju Pesonen
- Oslo Centre for Biostatistics and Epidemiology (OCBE), Oslo University Hospital Research Support Services
- Rodrigo Meneses
- Department of Medical Microbiology, University Medical Center Utrecht
- Henri Pesonen
- Department of Biostatistics, Faculty of Medicine, University of Oslo
- John A. Lees
- MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London
- Dorota Jamrozy
- Parasites and Microbes, Wellcome Sanger Institute
- Stephen D. Bentley
- Parasites and Microbes, Wellcome Sanger Institute
- Val F. Lanza
- Bioinformatics Unit, IRYCIS
- Carmen Torres
- Department of Food and Agriculture, Area of Biochemistry and Molecular Biology, University of La Rioja
- Luisa Peixe
- UCIBIO/REQUIMTE, Laboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy, University of Porto
- Teresa M. Coque
- Department of Microbiology, Ramón y Cajal Institute for Health Research Ramón y Cajal University Hospital
- Julian Parkhill
- Wellcome Sanger Institute
- Anita C. Schürch
- Department of Medical Microbiology, University Medical Center Utrecht
- Rob J. L. Willems
- Department of Medical Microbiology, University Medical Center Utrecht
- Jukka Corander
- Department of Biostatistics, Faculty of Medicine, University of Oslo
- DOI
- https://doi.org/10.1038/s41467-021-21749-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Enterococcus faecalis is a commensal microorganism of animals, insects and humans, but also a nosocomial pathogen. Here, the authors analyse genomic sequences from E. faecalis isolates from animals and humans, and find that the last common ancestors of multiple hospital-associated lineages date to the pre-antibiotic era.
