Clinical Optometry (Nov 2019)
Monitoring and Management of the Patient with Stargardt Disease
Abstract
Maria Vittoria Cicinelli, Marco Battista, Vincenzo Starace, Maurizio Battaglia Parodi, Francesco Bandello Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Milan, ItalyCorrespondence: Maria Vittoria CicinelliDepartment of Ophthalmology, San Raffaele Vita-Salute University, Via Olgettina, 60, Milano 20132, ItalyTel +39 02 26432648Fax +39 02 26483643Email [email protected]: Stargardt disease (STGD1) represents one of the major common causes of inherited irreversible visual loss. Due to its high phenotypic and genotypic heterogeneity, STGD1 is a complex disease to understand. Non-invasive imaging, biochemical, and genetic advances have led to substantial improvements in unveiling the disease processes and novel promising therapeutic landscapes have been proposed. This review recapitulates the modalities for monitoring patients with STGD1 and the therapeutic options currently under investigation for the different stages of the disease.Keywords: Stargardt disease, inherited retinal dystrophy, multimodal imaging, optical coherence tomography, gene therapy
