Nature Communications (Mar 2017)
Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules
- Xiaofan Han,
- Pin Li,
- Zhenghao Yang,
- Xiaoshuai Huang,
- Guoqin Wei,
- Yujie Sun,
- Xuya Kang,
- Xueting Hu,
- Qiuping Deng,
- Liangyi Chen,
- Aibin He,
- Yingqing Huo,
- Dong Li,
- Eric Betzig,
- Jincai Luo
Affiliations
- Xiaofan Han
- Laboratory of Vascular Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
- Pin Li
- Laboratory of Vascular Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
- Zhenghao Yang
- Laboratory of Vascular Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
- Xiaoshuai Huang
- The State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Laboratory of Institute of Molecular Medicine, Peking University
- Guoqin Wei
- Laboratory of Vascular Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
- Yujie Sun
- State Key Laboratory of Biomembrane and Membrane Biotechnology, Biodynamic Optical Imaging Center (BIOPIC), School of Life Sciences, Peking University
- Xuya Kang
- Laboratory of Vascular Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
- Xueting Hu
- Laboratory of Vascular Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
- Qiuping Deng
- Laboratory of Vascular Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
- Liangyi Chen
- The State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Laboratory of Institute of Molecular Medicine, Peking University
- Aibin He
- The State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Laboratory of Institute of Molecular Medicine, Peking University
- Yingqing Huo
- Laboratory of Vascular Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
- Dong Li
- Janelia Research Campus, Howard Hughes Medical Institute
- Eric Betzig
- Janelia Research Campus, Howard Hughes Medical Institute
- Jincai Luo
- Laboratory of Vascular Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University
- DOI
- https://doi.org/10.1038/ncomms14639
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
The adaptor protein zyxin is known for its mechanosensing function in the maintenance of actin network. Here the authors show that zyxin is key to blood homeostasis and thrombosis by controlling the endothelial release of von Willebrand factor and the formation of actin scaffolds on exocytic granules.
