Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal

Shantisree Sandeepani Rayagiri; Daniele Ranaldi; Alexander Raven; Nur Izzah Farhana Mohamad Azhar; Olivier Lefebvre; Peter S Zammit; Anne-Gaëlle Borycki

doi:10.1038/s41467-018-03425-3

Nature Communications (Mar 2018)

Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal

Shantisree Sandeepani Rayagiri,
Daniele Ranaldi,
Alexander Raven,
Nur Izzah Farhana Mohamad Azhar,
Olivier Lefebvre,
Peter S Zammit,
Anne-Gaëlle Borycki

Affiliations

Shantisree Sandeepani Rayagiri: Department of Biomedical Science, University of Sheffield, Firth Court
Daniele Ranaldi: Department of Biomedical Science, University of Sheffield, Firth Court
Alexander Raven: Department of Biomedical Science, University of Sheffield, Firth Court
Nur Izzah Farhana Mohamad Azhar: Department of Biomedical Science, University of Sheffield, Firth Court
Olivier Lefebvre: Inserm U1109 MN3T
Peter S Zammit: Randall Centre for Cell and Molecular Biophysics, Faculty of Life Sciences & Medicine King’s College London, New Hunt’s House
Anne-Gaëlle Borycki: Department of Biomedical Science, University of Sheffield, Firth Court

DOI: https://doi.org/10.1038/s41467-018-03425-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Extracellular matrix (ECM) remodelling is thought to have effects on muscle stem cells that support muscle homeostasis. Here the authors show ECM remodeling controls satellite cell self-renewal through deposition of laminin-α1 into the satellite cell niche.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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