TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling

Rongxuan Zhu; Olivier Gires; Liqun Zhu; Jun Liu; Junjian Li; Hao Yang; Gaoda Ju; Jing Huang; Weiyu Ge; Yi Chen; Zhimin Lu; Hongxia Wang

doi:10.1038/s41467-019-10739-3

Nature Communications (Jun 2019)

TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling

Rongxuan Zhu,
Olivier Gires,
Liqun Zhu,
Jun Liu,
Junjian Li,
Hao Yang,
Gaoda Ju,
Jing Huang,
Weiyu Ge,
Yi Chen,
Zhimin Lu,
Hongxia Wang

Affiliations

Rongxuan Zhu: Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Olivier Gires: Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University of Munich
Liqun Zhu: Liyang People’s Hospital
Jun Liu: Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Junjian Li: Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Hao Yang: Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences
Gaoda Ju: Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Jing Huang: School of Pharmaceutical Science and Technology, Dalian University of Technology
Weiyu Ge: Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Yi Chen: Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Zhimin Lu: Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine
Hongxia Wang: Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-10739-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Tetraspanin 8 (TSPAN8) has been implicated in a number of different tumours, but the underlying mechanisms remain unclear. Here, in breast cancer the authors highlight a role for TSPAN8 in promoting tumorigenesis through the activation of Hedgehog signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal