Nature Communications (Jul 2018)
PRMT5-mediated regulation of developmental myelination
- Antonella Scaglione,
- Julia Patzig,
- Jialiang Liang,
- Rebecca Frawley,
- Jabez Bok,
- Angeliki Mela,
- Camila Yattah,
- Jingxian Zhang,
- Shun Xie Teo,
- Ting Zhou,
- Shuibing Chen,
- Emily Bernstein,
- Peter Canoll,
- Ernesto Guccione,
- Patrizia Casaccia
Affiliations
- Antonella Scaglione
- Neuroscience Initiative at the Advanced Science Research Center of the Graduate Center of The City University of New York
- Julia Patzig
- Neuroscience Initiative at the Advanced Science Research Center of the Graduate Center of The City University of New York
- Jialiang Liang
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Rebecca Frawley
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Jabez Bok
- Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research)
- Angeliki Mela
- Department of Pathology and Cell Biology, Columbia University Medical Center
- Camila Yattah
- Neuroscience Initiative at the Advanced Science Research Center of the Graduate Center of The City University of New York
- Jingxian Zhang
- Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research)
- Shun Xie Teo
- Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research)
- Ting Zhou
- Room A-829, Weill Cornell Medical College
- Shuibing Chen
- Room A-829, Weill Cornell Medical College
- Emily Bernstein
- Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Peter Canoll
- Department of Pathology and Cell Biology, Columbia University Medical Center
- Ernesto Guccione
- Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Patrizia Casaccia
- Neuroscience Initiative at the Advanced Science Research Center of the Graduate Center of The City University of New York
- DOI
- https://doi.org/10.1038/s41467-018-04863-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Myelin-forming cells derive from oligodendrocyte progenitors. Here the authors identify histone arginine methyl-transferase PRMT5 as critical for developmental myelination by modulating the cross-talk between histone arginine methylation and lysine acetylation, to favor differentiation.
