Nature Communications (Jul 2024)
Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm
- Yuchao Jiang,
- Cheng Luo,
- Jijun Wang,
- Lena Palaniyappan,
- Xiao Chang,
- Shitong Xiang,
- Jie Zhang,
- Mingjun Duan,
- Huan Huang,
- Christian Gaser,
- Kiyotaka Nemoto,
- Kenichiro Miura,
- Ryota Hashimoto,
- Lars T. Westlye,
- Genevieve Richard,
- Sara Fernandez-Cabello,
- Nadine Parker,
- Ole A. Andreassen,
- Tilo Kircher,
- Igor Nenadić,
- Frederike Stein,
- Florian Thomas-Odenthal,
- Lea Teutenberg,
- Paula Usemann,
- Udo Dannlowski,
- Tim Hahn,
- Dominik Grotegerd,
- Susanne Meinert,
- Rebekka Lencer,
- Yingying Tang,
- Tianhong Zhang,
- Chunbo Li,
- Weihua Yue,
- Yuyanan Zhang,
- Xin Yu,
- Enpeng Zhou,
- Ching-Po Lin,
- Shih-Jen Tsai,
- Amanda L. Rodrigue,
- David Glahn,
- Godfrey Pearlson,
- John Blangero,
- Andriana Karuk,
- Edith Pomarol-Clotet,
- Raymond Salvador,
- Paola Fuentes-Claramonte,
- María Ángeles Garcia-León,
- Gianfranco Spalletta,
- Fabrizio Piras,
- Daniela Vecchio,
- Nerisa Banaj,
- Jingliang Cheng,
- Zhening Liu,
- Jie Yang,
- Ali Saffet Gonul,
- Ozgul Uslu,
- Birce Begum Burhanoglu,
- Aslihan Uyar Demir,
- Kelly Rootes-Murdy,
- Vince D. Calhoun,
- Kang Sim,
- Melissa Green,
- Yann Quidé,
- Young Chul Chung,
- Woo-Sung Kim,
- Scott R. Sponheim,
- Caroline Demro,
- Ian S. Ramsay,
- Felice Iasevoli,
- Andrea de Bartolomeis,
- Annarita Barone,
- Mariateresa Ciccarelli,
- Arturo Brunetti,
- Sirio Cocozza,
- Giuseppe Pontillo,
- Mario Tranfa,
- Min Tae M. Park,
- Matthias Kirschner,
- Foivos Georgiadis,
- Stefan Kaiser,
- Tamsyn E. Van Rheenen,
- Susan L. Rossell,
- Matthew Hughes,
- William Woods,
- Sean P. Carruthers,
- Philip Sumner,
- Elysha Ringin,
- Filip Spaniel,
- Antonin Skoch,
- David Tomecek,
- Philipp Homan,
- Stephanie Homan,
- Wolfgang Omlor,
- Giacomo Cecere,
- Dana D. Nguyen,
- Adrian Preda,
- Sophia I. Thomopoulos,
- Neda Jahanshad,
- Long-Biao Cui,
- Dezhong Yao,
- Paul M. Thompson,
- Jessica A. Turner,
- Theo G. M. van Erp,
- Wei Cheng,
- ENIGMA Schizophrenia Consortium,
- Jianfeng Feng,
- ZIB Consortium
Affiliations
- Yuchao Jiang
- Institute of Science and Technology for Brain Inspired Intelligence, Fudan University
- Cheng Luo
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China
- Jijun Wang
- Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
- Lena Palaniyappan
- Douglas Mental Health University Institute, Department of Psychiatry, McGill University
- Xiao Chang
- Institute of Science and Technology for Brain Inspired Intelligence, Fudan University
- Shitong Xiang
- Institute of Science and Technology for Brain Inspired Intelligence, Fudan University
- Jie Zhang
- Institute of Science and Technology for Brain Inspired Intelligence, Fudan University
- Mingjun Duan
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China
- Huan Huang
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China
- Christian Gaser
- Department of Psychiatry and Psychotherapy, Jena University Hospital
- Kiyotaka Nemoto
- Department of Psychiatry, Division of Clinical Medicine, Institute of Medicine, University of Tsukuba
- Kenichiro Miura
- Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry
- Ryota Hashimoto
- Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry
- Lars T. Westlye
- Department of Psychology, University of Oslo
- Genevieve Richard
- Department of Psychology, University of Oslo
- Sara Fernandez-Cabello
- Department of Psychology, University of Oslo
- Nadine Parker
- NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Ole A. Andreassen
- NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
- Tilo Kircher
- Department of Psychiatry and Psychotherapy, Philipps Universität Marburg
- Igor Nenadić
- Department of Psychiatry and Psychotherapy, Philipps Universität Marburg
- Frederike Stein
- Department of Psychiatry and Psychotherapy, Philipps Universität Marburg
- Florian Thomas-Odenthal
- Department of Psychiatry and Psychotherapy, Philipps Universität Marburg
- Lea Teutenberg
- Department of Psychiatry and Psychotherapy, Philipps Universität Marburg
- Paula Usemann
- Department of Psychiatry and Psychotherapy, Philipps Universität Marburg
- Udo Dannlowski
- Institute for Translational Psychiatry, University of Münster
- Tim Hahn
- Institute for Translational Psychiatry, University of Münster
- Dominik Grotegerd
- Institute for Translational Psychiatry, University of Münster
- Susanne Meinert
- Institute for Translational Psychiatry, University of Münster
- Rebekka Lencer
- Institute for Translational Psychiatry, University of Münster
- Yingying Tang
- Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
- Tianhong Zhang
- Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
- Chunbo Li
- Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
- Weihua Yue
- Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)
- Yuyanan Zhang
- Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)
- Xin Yu
- Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)
- Enpeng Zhou
- Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)
- Ching-Po Lin
- Institute of Neuroscience, National Yang Ming Chiao Tung University
- Shih-Jen Tsai
- Department of Psychiatry, Taipei Veterans General Hospital
- Amanda L. Rodrigue
- Department of Psychiatry, Boston Children’s Hospital, Harvard Medical School
- David Glahn
- Department of Psychiatry, Boston Children’s Hospital, Harvard Medical School
- Godfrey Pearlson
- Olin Neuropsychiatry Research Center, Institute of Living
- John Blangero
- Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas of the Rio Grande Valley
- Andriana Karuk
- FIDMAG Germanes Hospitalàries Research Foundation
- Edith Pomarol-Clotet
- FIDMAG Germanes Hospitalàries Research Foundation
- Raymond Salvador
- FIDMAG Germanes Hospitalàries Research Foundation
- Paola Fuentes-Claramonte
- FIDMAG Germanes Hospitalàries Research Foundation
- María Ángeles Garcia-León
- FIDMAG Germanes Hospitalàries Research Foundation
- Gianfranco Spalletta
- Neuropsychiatry Laboratory, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation
- Fabrizio Piras
- Neuropsychiatry Laboratory, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation
- Daniela Vecchio
- Neuropsychiatry Laboratory, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation
- Nerisa Banaj
- Neuropsychiatry Laboratory, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation
- Jingliang Cheng
- Department of MRI, The First Affiliated Hospital of Zhengzhou University
- Zhening Liu
- National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University
- Jie Yang
- National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University
- Ali Saffet Gonul
- Ege University School of Medicine Department of Psychiatry, SoCAT Lab
- Ozgul Uslu
- Ege University Institute of Health Sciences Department of Neuroscience
- Birce Begum Burhanoglu
- Ege University Institute of Health Sciences Department of Neuroscience
- Aslihan Uyar Demir
- Ege University School of Medicine Department of Psychiatry, SoCAT Lab
- Kelly Rootes-Murdy
- Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) [Georgia State University, Georgia Institute of Technology, Emory University]
- Vince D. Calhoun
- Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) [Georgia State University, Georgia Institute of Technology, Emory University]
- Kang Sim
- West Region, Institute of Mental Health
- Melissa Green
- School of Clinical Medicine, University of New South Wales
- Yann Quidé
- School of Psychology, University of New South Wales
- Young Chul Chung
- Department of Psychiatry, Jeonbuk National University Hospital
- Woo-Sung Kim
- Department of Psychiatry, Jeonbuk National University Hospital
- Scott R. Sponheim
- Minneapolis VA Medical Center, University of Minnesota
- Caroline Demro
- Department of Psychiatry and Behavioral Sciences, University of Minnesota
- Ian S. Ramsay
- Department of Psychiatry and Behavioral Sciences, University of Minnesota
- Felice Iasevoli
- Section of Psychiatry - Department of Neuroscience, University “Federico II”
- Andrea de Bartolomeis
- Section of Psychiatry - Department of Neuroscience, University “Federico II”
- Annarita Barone
- Section of Psychiatry - Department of Neuroscience, University “Federico II”
- Mariateresa Ciccarelli
- Section of Psychiatry - Department of Neuroscience, University “Federico II”
- Arturo Brunetti
- Department of Advanced Biomedical Sciences, University “Federico II”
- Sirio Cocozza
- Department of Advanced Biomedical Sciences, University “Federico II”
- Giuseppe Pontillo
- Department of Advanced Biomedical Sciences, University “Federico II”
- Mario Tranfa
- Department of Advanced Biomedical Sciences, University “Federico II”
- Min Tae M. Park
- Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto
- Matthias Kirschner
- Division of Adult Psychiatry, Department of Psychiatry, University Hospitals of Geneva
- Foivos Georgiadis
- Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital University of Zurich
- Stefan Kaiser
- Division of Adult Psychiatry, Department of Psychiatry, University Hospitals of Geneva
- Tamsyn E. Van Rheenen
- Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne
- Susan L. Rossell
- Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University
- Matthew Hughes
- Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University
- William Woods
- Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University
- Sean P. Carruthers
- Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University
- Philip Sumner
- Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University
- Elysha Ringin
- National Institute of Mental Health
- Filip Spaniel
- National Institute of Mental Health
- Antonin Skoch
- National Institute of Mental Health
- David Tomecek
- National Institute of Mental Health
- Philipp Homan
- Psychiatric Hospital, University of Zurich
- Stephanie Homan
- Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich
- Wolfgang Omlor
- Psychiatric Hospital, University of Zurich
- Giacomo Cecere
- Psychiatric Hospital, University of Zurich
- Dana D. Nguyen
- Department of Pediatrics, University of California Irvine
- Adrian Preda
- Department of Psychiatry and Human Behavior, University of California Irvine
- Sophia I. Thomopoulos
- Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California
- Neda Jahanshad
- Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California
- Long-Biao Cui
- Department of Clinical Psychology, Fourth Military Medical University
- Dezhong Yao
- The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China
- Paul M. Thompson
- Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California
- Jessica A. Turner
- Psychiatry and Behavioral Health, Ohio State Wexner Medical Center
- Theo G. M. van Erp
- Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine
- Wei Cheng
- Institute of Science and Technology for Brain Inspired Intelligence, Fudan University
- ENIGMA Schizophrenia Consortium
- Jianfeng Feng
- Institute of Science and Technology for Brain Inspired Intelligence, Fudan University
- ZIB Consortium
- DOI
- https://doi.org/10.1038/s41467-024-50267-3
- Journal volume & issue
-
Vol. 15,
no. 1
pp. 1 – 15
Abstract
Abstract Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts from the ENIGMA, non-ENIGMA cohorts and public datasets. Using the Subtype and Stage Inference (SuStaIn) algorithm, we identify two distinct neurostructural subgroups by mapping the spatial and temporal ‘trajectory’ of gray matter change in schizophrenia. Subgroup 1 was characterized by an early cortical-predominant loss with enlarged striatum, whereas subgroup 2 displayed an early subcortical-predominant loss in the hippocampus, striatum and other subcortical regions. We confirmed the reproducibility of the two neurostructural subtypes across various sample sites, including Europe, North America and East Asia. This imaging-based taxonomy holds the potential to identify individuals with shared neurobiological attributes, thereby suggesting the viability of redefining existing disorder constructs based on biological factors.
