Nature Communications (Feb 2016)
Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders
- Takanobu Nakazawa,
- Ryota Hashimoto,
- Kazuto Sakoori,
- Yuki Sugaya,
- Asami Tanimura,
- Yuki Hashimotodani,
- Kazutaka Ohi,
- Hidenaga Yamamori,
- Yuka Yasuda,
- Satomi Umeda-Yano,
- Yuji Kiyama,
- Kohtarou Konno,
- Takeshi Inoue,
- Kazumasa Yokoyama,
- Takafumi Inoue,
- Shusuke Numata,
- Tohru Ohnuma,
- Nakao Iwata,
- Norio Ozaki,
- Hitoshi Hashimoto,
- Masahiko Watanabe,
- Toshiya Manabe,
- Tadashi Yamamoto,
- Masatoshi Takeda,
- Masanobu Kano
Affiliations
- Takanobu Nakazawa
- Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo
- Ryota Hashimoto
- Department of Psychiatry, Osaka University Graduate School of Medicine
- Kazuto Sakoori
- Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo
- Yuki Sugaya
- Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo
- Asami Tanimura
- Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo
- Yuki Hashimotodani
- Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo
- Kazutaka Ohi
- Department of Psychiatry, Osaka University Graduate School of Medicine
- Hidenaga Yamamori
- Department of Psychiatry, Osaka University Graduate School of Medicine
- Yuka Yasuda
- Department of Psychiatry, Osaka University Graduate School of Medicine
- Satomi Umeda-Yano
- Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine
- Yuji Kiyama
- Division of Neuronal Network, Institute of Medical Science, The University of Tokyo
- Kohtarou Konno
- Department of Anatomy, Hokkaido University Graduate School of Medicine
- Takeshi Inoue
- Division of Oncology, Institute of Medical Science, The University of Tokyo
- Kazumasa Yokoyama
- Division of Oncology, Institute of Medical Science, The University of Tokyo
- Takafumi Inoue
- Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University
- Shusuke Numata
- Department of Psychiatry, Course of Integrated Brain Sciences, School of Medicine, University of Tokushima
- Tohru Ohnuma
- Department of Psychiatry, Juntendo University School of Medicine
- Nakao Iwata
- Department of Psychiatry, Fujita Health University School of Medicine
- Norio Ozaki
- Department of Psychiatry, Nagoya University Graduate School of Medicine
- Hitoshi Hashimoto
- iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University
- Masahiko Watanabe
- Department of Anatomy, Hokkaido University Graduate School of Medicine
- Toshiya Manabe
- Division of Neuronal Network, Institute of Medical Science, The University of Tokyo
- Tadashi Yamamoto
- Division of Oncology, Institute of Medical Science, The University of Tokyo
- Masatoshi Takeda
- Department of Psychiatry, Osaka University Graduate School of Medicine
- Masanobu Kano
- Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo
- DOI
- https://doi.org/10.1038/ncomms10594
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 17
Abstract
The molecular mechanisms of neurotrophin receptor trafficking are only partially understood. Here the authors show that ARHGAP33 interacts with SORT1 to regulate TrkB trafficking, the dysfunction of which impairs synapse development and leads to schizophrenia-related behavioural abnormalities in mice.
