Effect of dopamine on limbic network connectivity at rest in Parkinson’s disease patients with freezing of gait

Quek Dione Y. L.; Taylor Natasha; Gilat Moran; Lewis Simon J. G.; Ehgoetz Martens Kaylena A.

doi:10.1515/tnsci-2022-0336

Translational Neuroscience (May 2024)

Effect of dopamine on limbic network connectivity at rest in Parkinson’s disease patients with freezing of gait

Quek Dione Y. L.,
Taylor Natasha,
Gilat Moran,
Lewis Simon J. G.,
Ehgoetz Martens Kaylena A.

Affiliations

Quek Dione Y. L.: Parkinson’s Disease Research Clinic, Brain and Mind Centre, University of Sydney, Sydney, Australia
Taylor Natasha: Parkinson’s Disease Research Clinic, Brain and Mind Centre, University of Sydney, Sydney, Australia
Gilat Moran: Neurorehabilitation Research Group (eNRGy), Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium
Lewis Simon J. G.: Parkinson’s Disease Research Clinic, Brain and Mind Centre, University of Sydney, Sydney, Australia
Ehgoetz Martens Kaylena A.: Parkinson’s Disease Research Clinic, Brain and Mind Centre, University of Sydney, Sydney, Australia

DOI: https://doi.org/10.1515/tnsci-2022-0336
Journal volume & issue: Vol. 15, no. 1
pp. 734 – 44

Abstract

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Freezing of gait (FOG) in Parkinson’s disease (PD) has a poorly understood pathophysiology, which hinders treatment development. Recent work showed a dysfunctional fronto-striato-limbic circuitry at rest in PD freezers compared to non-freezers in the dopamine “OFF” state. While other studies found that dopaminergic replacement therapy alters functional brain organization in PD, the specific effect of dopamine medication on fronto-striato-limbic functional connectivity in freezers remains unclear.

Published in Translational Neuroscience

ISSN: 2081-6936 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.degruyter.com/view/j/tnsci

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Abstract

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