Nature Communications (Dec 2021)

Dynamic regulation of N6,2′-O-dimethyladenosine (m6Am) in obesity

  • Moshe Shay Ben-Haim,
  • Yishay Pinto,
  • Sharon Moshitch-Moshkovitz,
  • Vera Hershkovitz,
  • Nitzan Kol,
  • Tammy Diamant-Levi,
  • Michal Schnaider Beeri,
  • Ninette Amariglio,
  • Haim Y. Cohen,
  • Gideon Rechavi

DOI
https://doi.org/10.1038/s41467-021-27421-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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m6A and m6Am are two prevalent mRNA modifications which are target for removal by the fat mass and obesity gene FTO. Here the authors capture the differential profile of these two modifications in the liver of obese mice and identify dynamic translation regulation by the m6Am modification.