The association between platelet to lymphocyte ratio and intraventicular hemorrhage in extremely immature infants

Abstract

Aim: Intraventricular hemorrhage (IVH) is a serious complication of premature births, especially in newborns with very low birth weight. It's important to be able to predict IVH. In this study, the relationship between platelet lymphocyte rate (PLR) and intraventricular hemorrhage in premature infants born under 28 weeks was examined. Material and methods: In the last 5 years, the medical records of infants with less than 28 weeks of gestational age (n=78) born in our hospital have been retrospectively examined. Obtained parameters from the whole blood count, especially the relationship between TLO and IVH were examined. Results: White blood cell and lymphocyte counts were significantly higher in severe IVH (grade 3-4), while TLO was found to be significantly lower (16048±5265 & 11972±10915, p=0.043; 10705±4537 & 6329±8101, p=0.007; 36.9±22.7 & 56.7±37.9 p=0.012, respectively). When the white blood cell, lymphocyte count, and PLR's diagnostic performance in predicting severe IVH were evaluated by ROC curve analyses, it was observed that the strongest performance belonged to the PLR (Area under the curve, AUC for WBC: 0.644; ALS: 0.687; PLR:0,691, respectively). PLR can estimate severe IVH with 94% sensitivity and 43% specificity at a cut-off value below 55.84. Conclusion: PLR can be used as a valuable marker for predicting IVH in extremely premature infants.

Keywords

• intraventriküler kanama
• trombosit lenfosit oranı
• prematüre
• platelet to lymphocyte ratio
• intraventicular hemorrhage
• premature