Vitamin D deficiency and increased inflammatory factor intercellular cell adhesion molecule-1 indicate severe leukoaraiosis in northern China

Abstract

Commonly plaguing in the frigid zone of the world, vitamin D deficiency, as indicated by low levels of 25-hydroxyvitamin D, exacerbated inflammatory responses and impaired endothelial function. Leukoaraiosis (LA) is a prevalent cause of cognitive dysfunction in the elderly and is potentially associated with inflammatory responses. This study aimed to investigate the impact of vitamin D on the severity of LA.

Keywords

• cerebral small vascular disease
• degenerative disease
• leukoaraiosis
• white matter hyperintensities
• lacunar infarction
• 25-hydroxyvitamin d
• icam-1
• fibrinogen-c
• inflammatory factor
• fazekas scale