The Various Roles of PEDF in Cancer

Mitra Elmi; Joshua H. Dass; Crispin R. Dass

doi:10.3390/cancers16030510

Cancers (Jan 2024)

The Various Roles of PEDF in Cancer

Mitra Elmi,
Joshua H. Dass,
Crispin R. Dass

Affiliations

Mitra Elmi: Curtin Medical School, Curtin University, Bentley, WA 6102, Australia
Joshua H. Dass: Curtin Medical School, Curtin University, Bentley, WA 6102, Australia
Crispin R. Dass: Curtin Medical School, Curtin University, Bentley, WA 6102, Australia

DOI: https://doi.org/10.3390/cancers16030510
Journal volume & issue: Vol. 16, no. 3
p. 510

Abstract

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Pigment epithelium-derived factor (PEDF) is a natural immunomodulator, anti-inflammatory, anti-angiogenic, anti-tumour growth and anti-metastasis factor, which can enhance tumour response to PEDF but can also conversely have pro-cancerous effects. Inflammation is a major cause of cancer, and it has been proven that PEDF has anti-inflammatory properties. PEDF’s functional activity can be investigated through measuring metastatic and metabolic biomarkers that will be discussed in this review.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

About the journal

Abstract

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