Pea Seedling Histaminase as a Novel Therapeutic Approach to Anaphylactic and Inflammatory Disorders

Emanuela Masini; Danielle Bani; Cosimo Marzocca; Mircea Alexandru Mateescu; Pier Francesco Mannaioni; Rodolfo Federico; Bruno Mondovì

doi:10.1100/tsw.2007.139

The Scientific World Journal (Jan 2007)

Pea Seedling Histaminase as a Novel Therapeutic Approach to Anaphylactic and Inflammatory Disorders

Emanuela Masini,
Danielle Bani,
Cosimo Marzocca,
Mircea Alexandru Mateescu,
Pier Francesco Mannaioni,
Rodolfo Federico,
Bruno Mondovì

Affiliations

Emanuela Masini: Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
Danielle Bani: Department of Anatomy, Histology and Forensic Medicine, Section of Histology, University of Florence, Italy
Cosimo Marzocca: Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
Mircea Alexandru Mateescu: Department of Chemistry and Biochemistry, Université du Québec à Montréal, Montreal (Quebec), Canada
Pier Francesco Mannaioni: Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
Rodolfo Federico: Department of Biology, University of Rome, Italy
Bruno Mondovì: Department of Biochemical Sciences “A. Rossi Fanelli”, Rome University “La Sapienza”, Rome, Italy

DOI: https://doi.org/10.1100/tsw.2007.139
Journal volume & issue: Vol. 7
pp. 888 – 902

Abstract

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Amine oxidases (AOs) are ubiquitous enzymes involved in the metabolism of biogenic amines. Copper AOs (Cu-AOs) catalyze the oxidative deamination of primary amine groups of several biogenic amines, such as putrescine, cadaverine, and histamine. In the present review, the effects of a plant amine oxidase (Cu-AO, histaminase, EC1.4.3.6) purified from pea seedlings in the modulation of IgE-mediated allergic reactions, and in the prevention of cardiac and splachnic postischemic reperfusion damage are reported.

Published in The Scientific World Journal

ISSN: 2356-6140 (Print); 1537-744X (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Technology; Medicine; Science
Website: https://onlinelibrary.wiley.com/journal/8086

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