Structure of a MacAB-like efflux pump from Streptococcus pneumoniae

Hong-Bo Yang; Wen-Tao Hou; Meng-Ting Cheng; Yong-Liang Jiang; Yuxing Chen; Cong-Zhao Zhou

doi:10.1038/s41467-017-02741-4

Nature Communications (Jan 2018)

Structure of a MacAB-like efflux pump from Streptococcus pneumoniae

Hong-Bo Yang,
Wen-Tao Hou,
Meng-Ting Cheng,
Yong-Liang Jiang,
Yuxing Chen,
Cong-Zhao Zhou

Affiliations

Hong-Bo Yang: Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China
Wen-Tao Hou: Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China
Meng-Ting Cheng: Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China
Yong-Liang Jiang: Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China
Yuxing Chen: Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China
Cong-Zhao Zhou: Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-017-02741-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Bacterial ATP-binding cassette (ABC)-type efflux pumps are involved in the resistance of antibiotics and antimicrobial peptides. Here authors report the crystal structures and ATPase activity of the MacAB-like efflux pump from Streptococcus pneumonia and describe a putative substrate transport mechanism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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