Nature Communications (Jul 2022)
Mast4 determines the cell fate of MSCs for bone and cartilage development
- Pyunggang Kim,
- Jinah Park,
- Dong-Joon Lee,
- Seiya Mizuno,
- Masahiro Shinohara,
- Chang Pyo Hong,
- Yealeen Jeong,
- Rebecca Yun,
- Hyeyeon Park,
- Sujin Park,
- Kyung-Min Yang,
- Min-Jung Lee,
- Seung Pil Jang,
- Hyun-Yi Kim,
- Seung-Jun Lee,
- Sun U. Song,
- Kyung-Soon Park,
- Mikako Tanaka,
- Hayato Ohshima,
- Jin Won Cho,
- Fumihiro Sugiyama,
- Satoru Takahashi,
- Han-Sung Jung,
- Seong-Jin Kim
Affiliations
- Pyunggang Kim
- GILO Institute, GILO Foundation
- Jinah Park
- GILO Institute, GILO Foundation
- Dong-Joon Lee
- Division in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry
- Seiya Mizuno
- Laboratory Animal Resource Center, University of Tsukuba
- Masahiro Shinohara
- Department of Rehabilitation for the Movement Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities
- Chang Pyo Hong
- Theragen Bio Co., Ltd
- Yealeen Jeong
- GILO Institute, GILO Foundation
- Rebecca Yun
- GILO Institute, GILO Foundation
- Hyeyeon Park
- GILO Institute, GILO Foundation
- Sujin Park
- GILO Institute, GILO Foundation
- Kyung-Min Yang
- Medpacto Inc.
- Min-Jung Lee
- Division in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry
- Seung Pil Jang
- Soo Hospital
- Hyun-Yi Kim
- Division in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry
- Seung-Jun Lee
- Division in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry
- Sun U. Song
- Research Institute, SCM Lifescience Inc.
- Kyung-Soon Park
- Department of Biomedical Science, College of Life Science, CHA University
- Mikako Tanaka
- Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences
- Hayato Ohshima
- Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences
- Jin Won Cho
- Department of Systems Biology and Glycosylation Network Research Center, Yonsei University
- Fumihiro Sugiyama
- Laboratory Animal Resource Center, University of Tsukuba
- Satoru Takahashi
- Laboratory Animal Resource Center, University of Tsukuba
- Han-Sung Jung
- Division in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry
- Seong-Jin Kim
- GILO Institute, GILO Foundation
- DOI
- https://doi.org/10.1038/s41467-022-31697-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Controlling fate decision of mesenchymal stromal cells (MSC) is important for their clinical application. Here the authors demonstrate that TGF-β-induced Mast4 suppression and Wnt-mediated Mast4 stabilization regulate MSC differentiation into cartilage and bone, respectively.
