Photo-functionalized TiO2 nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility

Jiang Chen; Sheng Dai; Luying Liu; Manfred F. Maitz; Yuzhen Liao; Jiawei Cui; Ansha Zhao; Ping Yang; Nan Huang; Yunbing Wang

Bioactive Materials (Jan 2021)

Photo-functionalized TiO2 nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility

Jiang Chen,
Sheng Dai,
Luying Liu,
Manfred F. Maitz,
Yuzhen Liao,
Jiawei Cui,
Ansha Zhao,
Ping Yang,
Nan Huang,
Yunbing Wang

Affiliations

Jiang Chen: National Engineering Research Center for Biomaterials, Sichuan University, No.29 of Wangjiang Road, Wuhou District, Chengdu, Sichuan, 610064, China; Institute of Biomaterials and Surface Engineering, Key Lab. for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, NO.111 of the North 1st Section of Second Ring Road, Chengdu, 610031, China
Sheng Dai: Institute of Biomaterials and Surface Engineering, Key Lab. for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, NO.111 of the North 1st Section of Second Ring Road, Chengdu, 610031, China
Luying Liu: Institute of Biomaterials and Surface Engineering, Key Lab. for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, NO.111 of the North 1st Section of Second Ring Road, Chengdu, 610031, China
Manfred F. Maitz: Institute of Biomaterials and Surface Engineering, Key Lab. for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, NO.111 of the North 1st Section of Second Ring Road, Chengdu, 610031, China; Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden, Hohe Strasse 6, Dresden, 01069, Germany
Yuzhen Liao: Institute of Biomaterials and Surface Engineering, Key Lab. for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, NO.111 of the North 1st Section of Second Ring Road, Chengdu, 610031, China
Jiawei Cui: Institute of Biomaterials and Surface Engineering, Key Lab. for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, NO.111 of the North 1st Section of Second Ring Road, Chengdu, 610031, China
Ansha Zhao: Institute of Biomaterials and Surface Engineering, Key Lab. for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, NO.111 of the North 1st Section of Second Ring Road, Chengdu, 610031, China
Ping Yang: Institute of Biomaterials and Surface Engineering, Key Lab. for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, NO.111 of the North 1st Section of Second Ring Road, Chengdu, 610031, China; Corresponding author.
Nan Huang: Institute of Biomaterials and Surface Engineering, Key Lab. for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, NO.111 of the North 1st Section of Second Ring Road, Chengdu, 610031, China
Yunbing Wang: National Engineering Research Center for Biomaterials, Sichuan University, No.29 of Wangjiang Road, Wuhou District, Chengdu, Sichuan, 610064, China; Corresponding author.

Journal volume & issue: Vol. 6, no. 1
pp. 45 – 54

Abstract

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Titanium dioxide (TiO2) has a long history of application in blood contact materials, but it often suffers from insufficient anticoagulant properties. Recently, we have revealed the photocatalytic effect of TiO2 also induces anticoagulant properties. However, for long-term vascular implant devices such as vascular stents, besides anticoagulation, also anti-inflammatory, anti-hyperplastic properties, and the ability to support endothelial repair, are desired. To meet these requirements, here, we immobilized silver nanoparticles (AgNPs) on the surface of TiO2 nanotubes (TiO2-NTs) to obtain a composite material with enhanced photo-induced anticoagulant property and improvement of the other requested properties. The photo-functionalized TiO2-NTs showed protein-fouling resistance, causing the anticoagulant property and the ability to suppress cell adhesion. The immobilized AgNPs increased the photocatalytic activity of TiO2-NTs to enhances its photo-induced anticoagulant property. The AgNP density was optimized to endow the TiO2-NTs with anti-inflammatory property, a strong inhibitory effect on smooth muscle cells (SMCs), and low toxicity to endothelial cells (ECs). The in vivo test indicated that the photofunctionalized composite material achieved outstanding biocompatibility in vasculature via the synergy of photo-functionalized TiO2-NTs and the multifunctional AgNPs, and therefore has enormous potential in the field of cardiovascular implant devices. Our research could be a useful reference for further designing of multifunctional TiO2 materials with high vascular biocompatibility.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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