生物医学转化 (Dec 2022)

Placental development and preeclampsia

  • Zhu Yuelin,
  • Li Qianqian,
  • Wang Yanling,
  • Shao Xuan

DOI
https://doi.org/10.12287/j.issn.2096-8965.20220403
Journal volume & issue
Vol. 3, no. 4
pp. 22 – 29

Abstract

Read online

Serving as the interface between the fetal and maternal environment during gestation, the placenta plays critical roles in the protection of the developing fetus and the maintenance of pregnancy. The placenta is responsible for blood perfusion and maternal-fetal material exchange, immune tolerance, and the regulation of pregnancy adaptation. Defects in placental development and functional maintenance are in tight association with adverse pregnancy outcomes such as preeclampsia. In this article, we reviewed recent advances on human trophoblast cell differentiation and the construction of placental functional units and discuss the pathogenic factors that may contribute to the occurrence of preeclampsia.

Keywords