Атеросклероз (Dec 2010)
Free-radical oxidation and atherosclerosis
Abstract
The important biological role reactive oxyradicals is described which are generated in various cells of able-bodied organisms, from unicellular up to highorganized, carrying out, due to a highest chemical reactivity and rather short lifetime, vital function alarm endocellular messengers and intercellular mediators for realization of the expedited and deferred adaptable rearrangement of a metabolism in tissues, including in system of a circulation. At the same time at appreciable accumulation in an organism of such moleculas them mediator function is transformed in damaging, caused by oxidation and destruction of histic lipids, proteins and nucleic acids with development of pathological damages of members and tissues. This concept is compounded with the numerous clinical items of information, that at the patients by an essential hypertension, atherosclerosis, ischemic illness of heart and myocardial infarction histic and the plasma level reactive oxyradicals and products oxidative damage cell’s biopolimers is many times higher than sizes observable at the able-bodied people even in the term of extreme situations, and pathological important in this case acts local and – or systemic hyperproduction of superoxidic and hydroxyl radicals, peroxinitrit, oxide of nitrogen, and other awake forms of oxygen.
