Influenza Virus Genomic Surveillance, Arizona, USA, 2023–2024

Rabia Maqsood; Matthew F. Smith; LaRinda A. Holland; Regan A. Sullins; Steven C. Holland; Michelle Tan; Gabrielle M. Hernandez Barrera; Alexis W. Thomas; Mario Islas; Joanna L. Kramer; Lora Nordstrom; Mary Mulrow; Michael White; Vel Murugan; Efrem S. Lim

doi:10.3390/v16050692

Viruses (Apr 2024)

Influenza Virus Genomic Surveillance, Arizona, USA, 2023–2024

Rabia Maqsood,
Matthew F. Smith,
LaRinda A. Holland,
Regan A. Sullins,
Steven C. Holland,
Michelle Tan,
Gabrielle M. Hernandez Barrera,
Alexis W. Thomas,
Mario Islas,
Joanna L. Kramer,
Lora Nordstrom,
Mary Mulrow,
Michael White,
Vel Murugan,
Efrem S. Lim

Affiliations

Rabia Maqsood: Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Matthew F. Smith: Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
LaRinda A. Holland: Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Regan A. Sullins: Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Steven C. Holland: Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Michelle Tan: Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Gabrielle M. Hernandez Barrera: Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Alexis W. Thomas: Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Mario Islas: Arizona State University Health Services, Tempe, AZ 85281, USA
Joanna L. Kramer: Division of Primary, Complex, and Adolescent Medicine, Phoenix Children’s Hospital, Phoenix, AZ 85016, USA
Lora Nordstrom: Valleywise Health Medical Center, Phoenix, AZ 85008, USA
Mary Mulrow: Valleywise Health Medical Center, Phoenix, AZ 85008, USA
Michael White: Valleywise Health Medical Center, Phoenix, AZ 85008, USA
Vel Murugan: Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Efrem S. Lim: Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA

DOI: https://doi.org/10.3390/v16050692
Journal volume & issue: Vol. 16, no. 5
p. 692

Abstract

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Influenza viruses are constantly evolving and are therefore monitored worldwide in the hope to reduce the burden of disease by annual updates to vaccine recommendations. We conducted genomic sequencing of 110 influenza A and 30 influenza B viruses from specimens collected between October 2023 and February 2024 in Arizona, USA. We identified mutations in the hemagglutinin (HA) antigenic sites as well as the neuraminidase (NA) gene in our samples. We also found no unique HA and NA mutations in vaccinated yet influenza-infected individuals. Real-time genomic sequencing surveillance is important to ensure influenza vaccine effectiveness.

Published in Viruses

ISSN: 1999-4915 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/viruses

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