Progress on the role of NLRP3 inflammasome in hyperuricemic nephropathy

DAI Zhixin, WANG Yumin

doi:10.16352/j.issn.1001-6325.2023.02.322

Jichu yixue yu linchuang (Feb 2023)

Progress on the role of NLRP3 inflammasome in hyperuricemic nephropathy

DAI Zhixin, WANG Yumin

Affiliations

DAI Zhixin, WANG Yumin: 1. Department of General Family Medicine, the Affiliated Hospital of Chifeng University, Chifeng 024005; ;2. Department of Respiratory and Critical Care Medicine,Aerospace Center Hospital,Peking University Aerospace School of Clinical Medicine, Beijing 100049, China

DOI: https://doi.org/10.16352/j.issn.1001-6325.2023.02.322
Journal volume & issue: Vol. 43, no. 2
pp. 322 – 326

Abstract

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Hyperuricemic nephropathy (HN) is a common clinical complication of hyperuricemia, leading to hyperuricemia-associated renal abnormalities. The present review sheds light on the mechanistic aspects pertaining to HN, emphasizing the role of nucleotide-binding oligomerization domain leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in the occurrence and development of HN.This review recommends pharmacological inhibition of NLRP3 infammasome as a therapeutic strategy of HN treatment.

hyperuricemic nephropathy|hyperuricemia|nlrp3 inflammasome|inhibitor

Published in Jichu yixue yu linchuang

ISSN: 1001-6325 (Print)
Publisher: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Country of publisher: China
LCC subjects: Medicine
Website: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/1001-6325/home.shtml

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