A case report of levetiracetam Ingestion and raise in Prothrombin time and International Normalized Ratio (INR)

Abstract

We report a case of raised Prothrombin Time (PT) and International Normalized Ratio (INR) in a young male after ingestion of 3500 mgs of Levetiracetam as a suicidal attempt. No thrombocytopenia or raised liver enzyme disturbances were noticed. There were no previous published reports of such findings. Previous published reports of platelet related dysfunction and some reports of thrombocytopenia would be discussed in the light of our findings. Introduction: levetiracetam (LEV) is an antiepileptic drug approved for adjunctive use in partial seizures by United States food and drug administration (FDA) in 1999. The maximum recommended dose is 3000 mg daily. It is known to have mild side effect profile with headache, somnolence, dizziness, infection and asthenia1. However, hematological side effects are rare. We report a case of suicidal attempt with LEV and prolonged Prothrombin time which resolved over time.