HYPERANDROGENISM OF PUBERTY AGE AS A FACTOR REDUCING FERTILITY

Abstract

Aim. Hyperandrogenism is a common cause of infertility in women. The onset of symptoms of hyperandrogenism takes place during puberty in the majority of women. Hyperandrogenism reduces reproductive potential,so early detection and development of its prognostic factors, allows us to solve serious problems of puberty and prevent infertility.Materials and methods. 113 adolescent girls with hyperandrogenism from 14 to 19 years were included. The control group consists of 25 healthy girls of a similar age. To confirm the prediction of decreased reproductive capacity were examined 35 women with hyperandrogenism from 19 to 36 years. In addition to routine methods of examination (anamnesis, physical examination, anthropometry, assessment of the hairline using Ferriman – Gallwey scale, ultrasound of the pelvic organs, the definition of the hormonal status (LH, FSH, prolactin, 17-OHP, estradiol, TSH, DHEAS-s, GHPG, testosterone), glucose, insulin, glucose tolerance test and dexamethasone suppression test when necessary.Results. We have proved the reduction of reproductive potential of adolescent girls with high free androgen index (FAI). When the FAI has increased from 36 to 100 conventional units it caused reduction of the reproductive capacity in 9.7 times in comparison with control group (χ2=56,24; p < 0.001; overall prediction accuracy of 92.8%).Conclusion. Free androgen index more than 36 conventional units is a high risk factor of reduced fertility.

Keywords

• гиперандрогения
• девочки-подростки
• синдром поликистозных яичников
• репродуктивный потенциал
• снижение фертильности
• прогнозирование