Nature Communications (Jun 2020)
Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression
- Lishay Parhi,
- Tamar Alon-Maimon,
- Asaf Sol,
- Deborah Nejman,
- Amjad Shhadeh,
- Tanya Fainsod-Levi,
- Olga Yajuk,
- Batya Isaacson,
- Jawad Abed,
- Naseem Maalouf,
- Aviram Nissan,
- Judith Sandbank,
- Einav Yehuda-Shnaidman,
- Falk Ponath,
- Jörg Vogel,
- Ofer Mandelboim,
- Zvi Granot,
- Ravid Straussman,
- Gilad Bachrach
Affiliations
- Lishay Parhi
- The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine
- Tamar Alon-Maimon
- The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine
- Asaf Sol
- The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine
- Deborah Nejman
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Amjad Shhadeh
- The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine
- Tanya Fainsod-Levi
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), Hebrew University-Hadassah Medical School
- Olga Yajuk
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), Hebrew University-Hadassah Medical School
- Batya Isaacson
- Department of Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), Hebrew University-Hadassah Medical School
- Jawad Abed
- The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine
- Naseem Maalouf
- The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine
- Aviram Nissan
- Department of General and Oncological Surgery-Surgery C, The Chaim Sheba Medical Center, Tel Hashomer
- Judith Sandbank
- The Pathology Institute, Maccabi Healthcare Services
- Einav Yehuda-Shnaidman
- The Pathology Institute, Maccabi Healthcare Services
- Falk Ponath
- Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Center for Infection Research (HZI)
- Jörg Vogel
- Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Center for Infection Research (HZI)
- Ofer Mandelboim
- Department of Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), Hebrew University-Hadassah Medical School
- Zvi Granot
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), Hebrew University-Hadassah Medical School
- Ravid Straussman
- Department of Molecular Cell Biology, Weizmann Institute of Science
- Gilad Bachrach
- The Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine
- DOI
- https://doi.org/10.1038/s41467-020-16967-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
High levels of Fusobacterium nucleatum have been associated with poor overall survival in patients with colorectal and esophageal cancer. Here, the authors show that F. nucleatum is abundant in breast cancer samples and that the colonization by F. nucleatum accelerates tumor growth and metastasis in preclinical breast cancer models.
