First detection of the mcr-1 colistin resistance gene in Escherichia coli from a patient with urinary tract infection in Myanmar

N. San; M.S. Aung; P.P. Thu; Y.Y. Myint; M.T. Aung; T. San; T.T. Mar; M.M. Lwin; W.W. Maw; M.S. Hlaing; N. Kobayashi

New Microbes and New Infections (Jul 2019)

First detection of the mcr-1 colistin resistance gene in Escherichia coli from a patient with urinary tract infection in Myanmar

N. San,
M.S. Aung,
P.P. Thu,
Y.Y. Myint,
M.T. Aung,
T. San,
T.T. Mar,
M.M. Lwin,
W.W. Maw,
M.S. Hlaing,
N. Kobayashi

Affiliations

N. San: Department of Microbiology, University of Medicine 2, Yangon, Myanmar
M.S. Aung: Sapporo Medical University School of Medicine, Sapporo, Japan
P.P. Thu: Department of Microbiology, University of Medicine 2, Yangon, Myanmar
Y.Y. Myint: Department of Microbiology, University of Medicine 2, Yangon, Myanmar
M.T. Aung: North Okkalapa General and Teaching Hospital, Yangon, Myanmar; Corresponding author: M. S. Aung, Department of Hygiene, Sapporo Medical University School of Medicine, S-1 W-17, Chuo-ku, Sapporo 060-8556, Japan.
T. San: Yangon Children's Hospital, Ministry of Health and Sports, Yangon, Myanmar
T.T. Mar: Department of Microbiology, University of Medicine 2, Yangon, Myanmar
M.M. Lwin: Department of Microbiology, University of Medicine 2, Yangon, Myanmar
W.W. Maw: Department of Microbiology, University of Medicine 2, Yangon, Myanmar
M.S. Hlaing: Department of Microbiology, University of Medicine 2, Yangon, Myanmar
N. Kobayashi: Sapporo Medical University School of Medicine, Sapporo, Japan

Journal volume & issue: Vol. 30

Abstract

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Colistin-resistance gene mcr-1 was detected in an Escherichia coli sample among 442 clinical isolates collected in a tertiary-care hospital in Yangon, Myanmar, in 2018. This isolate was classified into phylogroup A–ST23 complex and harboured blaCTX-M-15 and blaTEM-1, associated with multiple mutations in quinolone-resistance–determining regions in gyrA and parC. Keywords: colistin resistance, Escherichia coli, mcr-1, Myanmar, ST23 complex

Published in New Microbes and New Infections

ISSN: 2052-2975 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://www.sciencedirect.com/journal/new-microbes-and-new-infections

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