Nature Communications (Jun 2019)
XX sex chromosome complement promotes atherosclerosis in mice
- Yasir AlSiraj,
- Xuqi Chen,
- Sean E. Thatcher,
- Ryan E. Temel,
- Lei Cai,
- Eric Blalock,
- Wendy Katz,
- Heba M. Ali,
- Michael Petriello,
- Pan Deng,
- Andrew J. Morris,
- Xuping Wang,
- Aldons J. Lusis,
- Arthur P. Arnold,
- Karen Reue,
- Katherine Thompson,
- Patrick Tso,
- Lisa A. Cassis
Affiliations
- Yasir AlSiraj
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Xuqi Chen
- Integrative Biology and Physiology, University of California
- Sean E. Thatcher
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Ryan E. Temel
- Saha Cardiovascular Research Center, University of Kentucky
- Lei Cai
- Saha Cardiovascular Research Center, University of Kentucky
- Eric Blalock
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Wendy Katz
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Heba M. Ali
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- Michael Petriello
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Kentucky, and Lexington Veterans Affairs Medical Center
- Pan Deng
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Kentucky, and Lexington Veterans Affairs Medical Center
- Andrew J. Morris
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Kentucky, and Lexington Veterans Affairs Medical Center
- Xuping Wang
- Department of Microbiology, Immunology & Molecular Genetics, Human Genetics, College of Medicine, University of California
- Aldons J. Lusis
- Department of Microbiology, Immunology & Molecular Genetics, Human Genetics, College of Medicine, University of California
- Arthur P. Arnold
- Integrative Biology and Physiology, University of California
- Karen Reue
- Human Genetics, University of California
- Katherine Thompson
- Department of Statistics, University of Kentucky
- Patrick Tso
- Department of Pathology, University of Cincinnati
- Lisa A. Cassis
- Department of Pharmacology and Nutritional Sciences, University of Kentucky
- DOI
- https://doi.org/10.1038/s41467-019-10462-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Men and women differ in their risk of developing coronary artery disease, in part due to differences in their levels of sex hormones. Here, AlSiraj et al. show that the XX sex genotype regulates lipid metabolism and promotes atherosclerosis independently of sex hormones in mice.
