Nature Communications (Mar 2019)
Noninvasive sub-organ ultrasound stimulation for targeted neuromodulation
- Victoria Cotero,
- Ying Fan,
- Tea Tsaava,
- Adam M. Kressel,
- Ileana Hancu,
- Paul Fitzgerald,
- Kirk Wallace,
- Sireesha Kaanumalle,
- John Graf,
- Wayne Rigby,
- Tzu-Jen Kao,
- Jeanette Roberts,
- Chitresh Bhushan,
- Suresh Joel,
- Thomas R. Coleman,
- Stavros Zanos,
- Kevin J. Tracey,
- Jeffrey Ashe,
- Sangeeta S. Chavan,
- Christopher Puleo
Affiliations
- Victoria Cotero
- GE Global Research Center
- Ying Fan
- GE Global Research Center
- Tea Tsaava
- Feinstein Institute for Medical Research
- Adam M. Kressel
- Feinstein Institute for Medical Research
- Ileana Hancu
- GE Global Research Center
- Paul Fitzgerald
- GE Global Research Center
- Kirk Wallace
- GE Global Research Center
- Sireesha Kaanumalle
- GE Global Research Center
- John Graf
- GE Global Research Center
- Wayne Rigby
- GE Global Research Center
- Tzu-Jen Kao
- GE Global Research Center
- Jeanette Roberts
- GE Global Research Center
- Chitresh Bhushan
- GE Global Research Center
- Suresh Joel
- GE Global Research Center
- Thomas R. Coleman
- Feinstein Institute for Medical Research
- Stavros Zanos
- Feinstein Institute for Medical Research
- Kevin J. Tracey
- Feinstein Institute for Medical Research
- Jeffrey Ashe
- GE Global Research Center
- Sangeeta S. Chavan
- Feinstein Institute for Medical Research
- Christopher Puleo
- GE Global Research Center
- DOI
- https://doi.org/10.1038/s41467-019-08750-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Stimulation of peripheral nerve activity may be used to treat metabolic and inflammatory disorders, but current approaches need implanted devices. Here, the authors present a non-invasive approach, and show that ultrasound-mediated stimulation can be targeted to specific sub-organ locations in preclinical models and alter the response of metabolic and inflammatory neural pathways.
