Genomics & Informatics (Sep 2018)

Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer

  • Jong-Lyul Park,
  • Seon-Kyu Kim,
  • Jeong-Hwan Kim,
  • Seok Joong Yun,
  • Wun-Jae Kim,
  • Won Tae Kim,
  • Pildu Jeong,
  • Ho Won Kang,
  • Seon-Young Kim

DOI
https://doi.org/10.5808/GI.2018.16.3.71
Journal volume & issue
Vol. 16, no. 3
pp. 71 – 74

Abstract

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Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC.

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