Zhongguo aizheng zazhi (May 2022)
Genetic characteristics and prognosis of metastatic thyroid cancer in children
Abstract
The incidence rate of thyroid cancer increases with age. Although the incidence rate of thyroid cancer in children is far lower than in adults, thyroid cancer has become the fifth most common cancer among children aged 0-14 and the most common cancer among adolescents worldwide. Unlike thyroid cancer in adults, the increase in the incidence of thyroid cancer in children is more likely to be caused by genetic or environmental factors. Moreover, thyroid cancer in children tends to be late stage, and the recurrence rate is much higher than in adults. However, the relationship between molecular pathological characteristics and metastasis of thyroid cancer in children still needs to be further clarified. This review focused on the genetic changes of metastatic thyroid cancer in children in order to provide the reference for researchers and clinicians to better understand basic research, prevention and treatment of thyroid cancer in children.
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