Nature Communications (Jan 2023)
Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer
- Michael J. P. Crowley,
- Bhavneet Bhinder,
- Geoffrey J. Markowitz,
- Mitchell Martin,
- Akanksha Verma,
- Tito A. Sandoval,
- Chang-Suk Chae,
- Shira Yomtoubian,
- Yang Hu,
- Sahil Chopra,
- Diamile A. Tavarez,
- Paolo Giovanelli,
- Dingcheng Gao,
- Timothy E. McGraw,
- Nasser K. Altorki,
- Olivier Elemento,
- Juan R. Cubillos-Ruiz,
- Vivek Mittal
Affiliations
- Michael J. P. Crowley
- Department of Cardiothoracic Surgery, Weill Cornell Medicine
- Bhavneet Bhinder
- Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine
- Geoffrey J. Markowitz
- Department of Cardiothoracic Surgery, Weill Cornell Medicine
- Mitchell Martin
- Department of Cardiothoracic Surgery, Weill Cornell Medicine
- Akanksha Verma
- Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine
- Tito A. Sandoval
- Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine
- Chang-Suk Chae
- Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine
- Shira Yomtoubian
- Department of Cardiothoracic Surgery, Weill Cornell Medicine
- Yang Hu
- Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine
- Sahil Chopra
- Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine
- Diamile A. Tavarez
- Department of Cardiothoracic Surgery, Weill Cornell Medicine
- Paolo Giovanelli
- Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine
- Dingcheng Gao
- Department of Cardiothoracic Surgery, Weill Cornell Medicine
- Timothy E. McGraw
- Department of Cardiothoracic Surgery, Weill Cornell Medicine
- Nasser K. Altorki
- Department of Cardiothoracic Surgery, Weill Cornell Medicine
- Olivier Elemento
- Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine
- Juan R. Cubillos-Ruiz
- Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine
- Vivek Mittal
- Department of Cardiothoracic Surgery, Weill Cornell Medicine
- DOI
- https://doi.org/10.1038/s41467-022-35584-9
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
The IRE1α-XBP1 arm of the unfolded protein response (UPR) has been associated with immunosuppression and cancer progression. Here the authors show that IRE1α-XBP1 activation is associated with poor overall survival in patients with non-small cell lung cancer and that IRE1α loss in cancer cells promotes anti-tumor immune responses in lung cancer preclinical models.
